How Exeltur PD helps reverse Prediabetes

How Exeltur PD helps reverse Prediabetes

Exeltur PD is World’s Only Mouth-Dissolving Turmeric-Pterocarpus Lozenge
Exeltur PD is Sublingual Oleoresin-Curcumin Bioactive Gel
with the revolutionary Quicksorb Hydrogel Technology

Each soft gelatin lozenge contains–

Exeltur PD contains bioactive Curcumin made from the purest form of unadulterated Turmeric (Curcuma longa) extract, incorporated in an easy-to-absorb form.Curcuma longa has over 200 bioactive substances including curcumin and related substances (curcuminoids) besides turmeric oleoresins. Both of these factions reduce blood glucose levels. However, regular turmeric taken orally is poorly absorbed, rapidly metabolized and eliminated. Thus, the antidiabetic benefits of Curcumin are lost due to its poor bioavailability. To achieve these results high doses of turmeric are thus needed,

Mounting evidence from scientific studies shows that Curcumin exerts antioxidant, anti-inflammatory, anticancer, and neuroprotective activities. Curcumin lowers blood sugar in multiple ways, namely –

Stimulating insulin secretion from pancreatic cells;

Improving sensitivity of body cells to insulin (reducing insulin resistance);

Reducing oxidative stress and inflammation;

Reducing glucose production by liver, Stimulating utilization of glucose by the body.

Increasing immunity (immunomodulatory action)

How does curcumin achieve all this ?

• Curcumin prevents mobilisation of NF-kB (Nuclear factor kappa B) and hence prevents release of pro- inflammatory cytokines. 
(NF-kB is the inflammatory Master switchwhich when stimulated, is released from its inhibitory molecule IKB, there by allowing its movement to the cell nucleus where it switches on genes responsible for the production of a number of pro-inflammatory cytokines. Curcumin prevents NF-kBfrom entering the nucleus, thereby blocking inflammation at an early stage)
• Increases secretion of anti-inflammatory Adiponectin.
• Reduces macrophage infiltration,
• Stops TNF-alpha secretion resulting in reduced inflammation and insulin 
resistance.

An original article published in Diabetes Care (35- p2121-2127, 2012) titled 
Curcumin extract for prevention of Type 2 Diabetes is about a 9month curcumin intervention in a prediabetic population. This randomized, double- blinded, placebo-controlled trial included 240 subjects with criteria of prediabetes. 


The diabetes-related blood chemistries used to assess the diabetic progression, such as HbA1c, FPG (Fasting Plasma Glucose), and OGTT at 2 hours were 
significantly lower in the curcumin-treated group when compared with the placebo group in all visits at 3, 6, and 9 months. 


HOMA-β, C-peptide, and proinsulin/insulin ratio are related to β-cell functions. HOMA- β in the curcumin-treated group was increasingly elevated in all follow-up visits (at 3, 6, and 9 months) and became statistically significant at the final visit (9 months). Blood levels of C-peptide were found to be significantly lower in curcumin-treated group when compared with those of placebo group. This indicates that curcumin treatment results in better β -cell function.

HOMA-IR level is a clinical representative of insulin resistance. The average of HOMA-IR level of the curcumin-treated group were lower than those of placebo group at all follow- up visits (3, 6, and 9 months). The differences were significant, particularly at the 6- and 9-month visits.

Levels of adiponectin, an anti-inflammatory cytokine, in the placebo-treated group were virtually unchanged, whereas those of the curcumin-treated group were gradually elevated (at 3 and 6 months) and became significantly different from that of placebo-treated group at the final visit (9 months).

The curcumin-treated group showed a lower level of HOMA-IR and higher adiponectin when compared with the placebo group. This results in reduced insulin resistance.

After 9 months of treatment, 16.4% of subjects in the placebo group were diagnosed with Type2Diabetes, whereas none were diagnosed with Type2Diabetes in the curcumin-treated group.

Because inflammation is one of the main causes of β-cell degradation, the anti- inflammatory activity of curcumin is a key factor for the curcumin’s antidiabetic property.

The 9-month treatment with curcumin was safe. No adverse effect was caused by curcumin treatment when compared to the placebo treatment. Despite losing some body weight and Waist Circumference, all of the subjects treated with curcumin remained healthy.

Exeltur PD also has Pterocarpus marsupium (Vijayasar). The heartwood and bark of this tree has been extensively used in the treatment of diabetes for thousands of years. The major active principles include Pterostilbene, Marsuposide, Marsupin, Pteroside, Epicatechin etc.

Marsupsin and pterostilbene, have effects on several tissues by suppressing hepatic gluconeogenesis, stimulating glycolysis, inhibiting glucose absorption from the intestineetc.

A recent therapeutic strategy to control diabetes is the inhibition of SGLT2 (Sodium Glucose Linked Transporter 2). SGLT2 aids the active transport of glucose into the blood stream from the kidney. Blockade of SGLT2 prevents reabsorption of glucose and thus increases urinary glucose excretion and thus reducing plasma glucose levels. Pterostilbene a C-glycoside from Pterocarpus marsupium is a safe and effective SGLT2 inhibitor. Prevents the kidneys from reabsorbing glucose back into the blood.

Exeltur PD helps reverse Prediabetes by

Reducing Insulin Resistance,
Improving beta cell functioning,
Reducing Oxidative stress,
Reducing inflammation and
Preventing Kidneys from reabsorbing glucose form urine.